Publication date: 03/04/2018
argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, today announced that it will present complete data from the Phase 2 clinical trial of efgartigimod (ARGX-113) in myasthenia gravis at the 2018 American Academy of Neurology (AAN) Annual Meeting in Los Angeles, CA.
Details on the presentation are as follows:
Date & Time: Tuesday, April 24, 2018, 9:15 a.m. - 11:30 a.m. PT
Presentation Title: A double-blind placebo-controlled study to evaluate the safety and efficacy of
FcRn-antagonist efgartigimod (ARGX-113) in generalized myasthenia gravis
Investor Event and Webcast Information
argenx will host an investor event on Tuesday, April 24, 2018, beginning at 1:00 p.m. PT in Los Angeles to discuss the complete efgartigimod clinical data presented at AAN earlier that day. The event will be webcast live and can be accessed on the argenx website www.argenx.com or by clicking here.
Efgartigimod (ARGX-113) is an investigational therapy for IgG-mediated autoimmune diseases and was designed to exploit the natural interaction between IgG antibodies and the recycling receptor FcRn. ARGX-113 is the Fc-portion of an antibody that has been modified by the argenx proprietary ABDEG(TM) technology to increase its affinity for FcRn beyond that of normal IgG antibodies. As a result, ARGX-113 blocks antibody recycling through FcRn binding and leads to fast depletion of the autoimmune disease-causing IgG autoantibodies. The development work on ARGX-113 is done in close collaboration with Prof. E. Sally Ward (University of Texas Southwestern Medical and Texas A&M University Health Science Center, a part of Texas A&M University (TAMHSC)).
argenx is a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe auto-immune diseases and cancer. We are focused on developing product candidates with the potential to be either first-in-class against novel targets or best-in-class against known, but complex, targets in order to treat diseases with a significant unmet medical need. Our ability to execute on this focus is enabled by our suite of differentiated technologies. Our SIMPLE AntibodyTM Platform, based on the powerful llama immune system, allows us to exploit novel and complex targets, and our three antibody engineering technologies are designed to enable us to expand the therapeutic index of our product candidates.