Publication date: 17/07/2018
argenx (Euronext & Nasdaq: ARGX), a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, today announced that it has reached a preclinical milestone in its strategic collaboration with Shire plc. The milestone, for which an undisclosed payment has been received, was triggered by Shire exercising its exclusive option to in-license an antibody discovered and developed using the Company's proprietary SIMPLE Antibody(TM) platform and Fc engineering technologies.
"The exclusive option exercised by Shire is a testament to the power of our antibody platform and the excellent progress we have made in our strategic collaboration, discovering highly differentiated SIMPLE antibodies against select novel targets," said Hans de Haard, Chief Scientific Officer of argenx. "The productivity of this partnership demonstrates our continued investment in antibody discovery collaborations and complements the clinical development progress we are making with our wholly-owned programs."
argenx entered into an initial collaboration with Shire in 2012 to discover, develop and commercialize human therapeutic antibodies against novel targets to address diverse, rare and unmet diseases. In 2014, the collaboration was expanded to provide Shire with a sublicense to the entire suite of argenx discovery technologies. Under the terms of that agreement, Shire may exercise exclusive options to license, develop and commercialize arising programs, in return for milestone and royalty payments upon achievement of specified development, regulatory and commercial milestones.
argenx is a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe auto-immune diseases and cancer. The company is focused on developing product candidates with the potential to be either first-in-class against novel targets or best-in-class against known, but complex, targets in order to treat diseases with a significant unmet medical need. argenx' ability to execute on this focus is enabled by its suite of differentiated technologies. The SIMPLE AntibodyTM Platform, based on the powerful llama immune system, allows argenx to exploit novel and complex targets, and the three antibody engineering technologies are designed to enable expansion of the therapeutic index of the company's product candidates.