argenx awarded €2.6 million VLAIO grant to explore new applications of ABDEG technology


argenx (Euronext & Nasdaq: ARGX) a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe autoimmune diseases and cancer, announced today that it has received a €2.6 million grant from the Flanders Innovation and Entrepreneurship (VLAIO) agency. The grant will be used to explore new applications and modes of action of argenx’s proprietary ABDEG™ technology, the Fc engineering technology used in the design of efgartigimod (ARGX-113) to augment the clearance of disease-causing autoantibodies.


“We are very pleased to receive this support from VLAIO, an organization that has enabled the steady growth of highly competitive Flemish biotechnology companies. By further exploring the potential of ABDEG™, our Fc engineering technology used in the design of our lead candidate efgartigimod, we hope to gain more insights on the target FcRn. This grant will allow us to further explore the potential of our antibody technology and scientific understanding of FcRn biology, with the possibility of developing additional innovative therapies for severe autoimmune indications,” commented Michael Saunders, Vice President of External Research at argenx.

The €2.6 million subsidy from VLAIO was granted to argenx through its Innovative Access Program (IAP) to fund new research around the proprietary ABDEG™ technology. argenx believes the IAP creates a foundation to build upon its unique and sustainable pipeline while providing access for its cutting edge antibody discovery technologies to centers of novel target research.


About SIMPLE AntibodyTM Platform
argenx’s technology suite consists of four complementary platforms. The proprietary SIMPLE Antibody™ discovery platform enables the discovery of antibodies targeting novel, complex disease targets, and has generated antibody leads with attributes beyond those attainable using current platforms. The Fc engineering technologies NHance®, ABDEG™ and POTELLIGENT® have the potential to further augment the intrinsic therapeutic functionalities of our antibody leads by prolonging product residence time in the human body, enhancing the clearance of either disease targets or pathogenic antibodies and enhancing antibody cell killing through antibody-dependent cell-mediated cytotoxicity. These technology platforms can be applied either individually or in combination yielding differentiated therapeutic antibodies with multiple modes of action.

About the Innovative Access Program
Through the IAP, argenx collaborates closely with academic centers of excellence and emerging biotechnology companies, bringing cutting-edge antibody discovery technologies to the heart of novel target research. The extraordinary diversity of the immune repertoires comprising its SIMPLE AntibodyTM Platform streamlines target validation, transforming novel protein discoveries into next generation therapeutic antibody programs.

About argenx
argenx is a clinical-stage biotechnology company developing a deep pipeline of differentiated antibody-based therapies for the treatment of severe auto-immune diseases and cancer. The company is focused on developing product candidates with the potential to be either first-in-class against novel targets or best-in-class against known, but complex, targets in order to treat diseases with a significant unmet medical need. argenx’s ability to execute on this focus is enabled by its suite of differentiated technologies. The SIMPLE AntibodyTM Platform, based on the powerful llama immune system, allows argenx to exploit novel and complex targets, and its three complementary Fc engineering technologies are designed to expand the therapeutic index of its product candidates.



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