Publication date: 05/08/2019
Biocartis Group NV (the ‘Company’ or ‘Biocartis’), an innovative molecular diagnostics company (Euronext Brussels: BCART), today announces that a study1 poster on the performance of the Idylla™ NRAS-BRAF Mutation Assay (RUO2) will be presented by Dr. Gregory Tsongalis (Director, Laboratory for Clinical Genomics and Advanced Technology of the Dartmouth-Hitchcock Medical Center) at the 71st AACC (American Association for Clinical Chemistry) Annual Scientific Meeting taking place between 4-8 August in Anaheim, CA (US).
The study concludes that the Idylla™ system offers rapid and accurate testing of NRAS and BRAF mutations in melanoma directly from FFPE3 tissue, and that its simplicity and ease of use compared to other available molecular techniques make it suitable for small centers that lack specifically trained staff and infrastructure. Furthermore, the study concludes that the Idylla™ system can also complement NGS (Next-Generation Sequencing) by providing much faster turnaround times.
In the study, twenty-two archived FFPE melanoma tissue specimens were tested on the Idylla™ system using the Idylla™ NRAS-BRAF Mutation Assay (RUO). Among these samples, eight had a mutation in BRAF, six had a mutation in NRAS, and eight had no mutations in BRAF or NRAS as determined by previous NGS testing4. The Idylla™ system successfully detected mutations in BRAF and NRAS and results were in full agreement with those previously obtained by NGS. Idylla™ produced results quickly with a turnaround time of approximately two hours.
Dr. Gregory Tsongalis, PhD, Director of the Laboratory for Clinical Genomics and Advanced Technology at Dartmouth-Hitchcock Medical Center, explains: “The Idylla™ system has the potential to play a significant role in rapid screening for actionable mutations prior to NGS analysis, also for small laboratory centers that lack staff with molecular diagnostics training and infrastructure.”
The poster will be presented on 7 August 2019 by Dr. Gregory Tsongalis, PhD, Director, Laboratory for Clinical Genomics and Advanced Technology at Dartmouth-Hitchcock Medical Center at the 71st AACC Annual Scientific Meeting in Anaheim, CA (US).
Biocartis (Euronext Brussels: BCART) is an innovative molecular diagnostics (MDx) company providing next generation diagnostic solutions aimed at improving clinical practice for the benefit of patients, clinicians, payers and industry. Biocartis' proprietary MDx Idylla™ platform is a fully automated sample-to-result, real-time PCR (Polymerase Chain Reaction) system that offers accurate, highly reliable molecular information from virtually any biological sample in virtually any setting. Biocartis is developing and marketing a continuously expanding test menu addressing key unmet clinical needs in oncology. This area represents the fastest growing segment of the MDx market worldwide. Today, Biocartis offers tests supporting melanoma, colorectal and lung cancer. More information: www.biocartis.com. Press Photo Library available here. Follow us on Twitter: @Biocartis_.
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1 M. Rabie Al-Turkmani et al., ‘Evaluation of a Cartridge-Based System for Rapid Detection of BRAF and NRAS Mutations in Melanoma’, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, first published at the 71st AACC Annual scientific meeting & clinical lab expo, 4-8 August 2019, Anaheim (CA), US, available on https://www.abstractsonline.com/pp8/#!/6831/presentation/566.
2 Research Use Only, not for use in diagnostic procedures.
3 Formalin Fixed, Paraffin Embedded.
4 Using the Ion AmpliSeq 50-gene Cancer Hotspot Panel v2 (Thermo Fisher Scientific).