Publication date: 19/12/2019
Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing innovative back of the eye treatments to preserve vision in patients with diabetic eye disease, announces it is to focus its activities on the clinical development of THR-149 and THR-687 as potential VEGF independent treatments for Diabetic Macular Edema (DME). THR-149 is a novel potent plasma kallikrein inhibitor while THR-687 is a Pan-RGD integrin inhibitor, both of which have the potential to treat a broad range of patients with diabetic eye disease.
Oxurion’s clinical pipeline now comprises:
Patrik De Haes, M.D., CEO of Oxurion, said: “We believe that with THR-149 and THR-687 we have the opportunity to become a global leader in providing retina physicians with novel VEGF independent treatment options for patients with DME. There is clear need for novel medicines that act via VEGF independent pathways, to address many of the limitations of the VEGF inhibitors, the current standard of care for DME. It is estimated that 40% of DME patients treated with anti-VEGF do not, or sub optimally respond to anti-VEGF treatment.
Given the attractiveness of the VEGF independent opportunity, and our confidence in our novel compounds’ ability to address this clear unmet medical need, we have decided to make no further investment in the development of THR-317. This reflects the competitive nature of the VEGF market and the mixed Phase 2 results with THR-317 which we released in August 2019. Results from the on-going Mactel-1 study with THR-317 are expected to be presented at a scientific conference in 2020.
The decisions we have announced today will simplify our organizational structure, allowing us to focus our resources on what we believe are two of the most exciting potential new therapies for diabetic eye disease currently in the clinic.”
Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing a pipeline of novel clinical drug candidates acting on VEGF-independent pathways for the treatment of diabetic eye disease, a leading cause of blindness in people of working age worldwide.
Oxurion’s clinical pipeline comprises:
Oxurion is headquartered in Leuven, Belgium, and is listed on the Euronext Brussels exchange under the symbol OXUR. More information is available at www.oxurion.com.